Zixuan (Eleanor) Zhang

Zixuan (Eleanor) Zhang

PhD candidate in Biostatistics at USC

Publications

You can also find my articles on my Google Scholar profile.

Genes with differential expression across ancestries are enriched in ancestry-specific disease effects likely due to gene-by-environment interactions

Published in American Journal of Human Genetics, 2024

We characterized genes differentially expressed across ancestries (ancDE genes) at the cell-type level by leveraging single-cell RNA-sequencing data from multiple ancestries.

Recommended citation: Wang, J., Zhang, Z., Lu, Z., Mancuso, N., and Gazal, S. (2024). Genes with differential expression across ancestries are enriched in ancestry-specific disease effects likely due to gene-by-environment interactions. Am. J. Hum. Genet.
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Inferring causal cell types of human diseases and risk variants from candidate regulatory elements

Published in medRxiv (preprint), 2024

We proposed methods to leverage cell-type-specific CREs to fine-map causal cell types for a trait and for its candidate causal variants.

Recommended citation: Kim, A., Zhang, Z., Legros, C., Lu, Z., de Smith, A., Moore, J.E., Mancuso, N., and Gazal, S. (2024). Inferring causal cell types of human diseases and risk variants from candidate regulatory elements. medRxiv.
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A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits using GWAS summary statistics

Published in American Journal of Human Genetics, 2023

We proposed a scalable factor analysis model to identify and characterize pleiotropic components using biobank GWAS summary data.

Recommended citation: Zhang, Z., Jung, J., Kim, A., Suboc, N., Gazal, S., and Mancuso, N. (2023). A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits using GWAS summary statistics. Am. J. Hum. Genet. 110, 1863–1874.
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