Posts by Collection

portfolio

FactorGo

github link: https://github.com/mancusolab/FactorGo

Other softwares from Mancuso Lab

github link: https://github.com/mancusolab

publications

A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits using GWAS summary statistics

Published in American Journal of Human Genetics, 2023

We proposed a scalable factor analysis model to identify and characterize pleiotropic components using biobank GWAS summary data.

Recommended citation: Zhang, Z., Jung, J., Kim, A., Suboc, N., Gazal, S., and Mancuso, N. (2023). A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits using GWAS summary statistics. Am. J. Hum. Genet. 110, 1863–1874.
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Inferring causal cell types of human diseases and risk variants from candidate regulatory elements

Published in medRxiv (preprint), 2024

We proposed methods to leverage cell-type-specific CREs to fine-map causal cell types for a trait and for its candidate causal variants.

Recommended citation: Kim, A., Zhang, Z., Legros, C., Lu, Z., de Smith, A., Moore, J.E., Mancuso, N., and Gazal, S. (2024). Inferring causal cell types of human diseases and risk variants from candidate regulatory elements. medRxiv.
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talks

A variational Bayesian approach to characterize pleiotropic components across thousands of human diseases and complex traits using GWAS summary statistics

Talk
1. Platform Talk in statistical genetics, ASHG 2022
2. Invited talk in Dr. Xiang Zhou’s group at University of Michigan, 2024
Poster
1. Computational Genomics Summer Institute 2023
2. Probabilistic Modeling in Genomics conference 2023
3. ASHG 2021